By Jeffrey L. Platt
Across the world well-known scientists, clinicians, and technologists overview and clarify the elemental molecular and mobile biology that has been utilized to the rising box of transplant immunology and xenotransplantation, and what impression those advances may perhaps optimally have on drugs and technology. The authoritative specialists writing here-many of whom made the elemental discoveries underlying the new advances-examine the organic and immunological hurdles to xenotransplantation, illuminating how the immune approach interacts with the xenograft and laying a pragmatic origin for using genetic engineering and animal transplants within the remedy of human sickness.
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Extra resources for Xenotransplantation: Basic Research and Clinical Applications
Dalmasso AP, Vercellotti GM, Platt JL, Bach FH. Inhibition of complementmediated endothelial cell cytotoxicity by decay accelerating factor: potential for prevention of xenograft hyperacute rejection. Transplantation 1991; 52:530–533. 105. Matsuo S, Ichida S, Takizawa H, et al. In vivo effects of monoclonal antibodies that functionally inhibit complement regulatory proteins in rats. J Exp Med 1994; 180:1619–1627. 106. Miyagawa S, Shirakura R, Matsumiya G, et al. Test for ability of decay-accelerating factor (DAF, CD55) and CD59 to alleviate complement-mediated damage of xeno-erythrocytes.
Johnston P, Lim S, Wright L, White D. Hyperacute xenograft rejection takes place in the complete absence of antibodies but requires the presence of functional complement. Transplant Proc 1991; 23:877–884. 99. Dalmasso AP, Platt JL. Prevention of complement-mediated activation of xenogeneic endothelial cells in an in vitro model of xenograft hyperacute rejection by C1 inhibitor. Transplantation 1993; 56:1171–1176. 100. Johnston PS, Wang M-W, Lim SML, Wright LJ, White DJG. Discordant xenograft rejection in an antibody-free model.
Eur J Immunol 1991; 21:2887–2890. 118. Inverardi L, Samaja M, Motterlini R, Mangili F, Bender JR, Pardi R. Early recognition of a discordant xenogeneic organ by human circulating lymphocytes. J Immunol 1992; 149:1416–1423. 119. Lanier LL, Phillips JH. Inhibitory MHC class I receptors on NK cells and T cells. Immunol Today 1996; 17:86–91. 38 Platt 120. Collins BH, Chari RS, Magee JC, et al. Mechanisms of injury in porcine livers perfused with blood of humans with fulminant hepatic failure. Transplantation 1994; 58:1162–1171.