Download The Blind Spot: Science and the Crisis of Uncertainty by William Byers PDF

By William Byers

In today's unpredictable and chaotic global, we glance to technology to supply sure bet and answers--and frequently blame it while issues get it wrong. The Blind Spot finds why our religion in medical simple task is a perilous phantasm, and the way basically by way of embracing science's inherent ambiguities and paradoxes will we actually get pleasure from its attractiveness and harness its potential.

Crackling with insights into our so much puzzling modern dilemmas, from weather switch to the worldwide monetary meltdown, this ebook demanding situations our so much sacredly held ideals approximately technological know-how, expertise, and development. whilst, it exhibits how the key to raised technology are available the place we least anticipate it--in the doubtful, the ambiguous, and the necessarily unpredictable. William Byers explains why the subjective aspect in medical inquiry is in reality what makes it so dynamic, and deftly balances the necessity for sure bet and rigor in technology with the both very important desire for creativity, freedom, and downright ask yourself. Drawing on an array of interesting examples--from Wall Street's overreliance on algorithms to supply walk in the park in doubtful markets, to undecidable difficulties in arithmetic and computing device technology, to Georg Cantor's paradoxical yet real statement approximately infinity--Byers demonstrates how we will and needs to study from the life of blind spots in our clinical and mathematical understanding.

The Blind Spot bargains a wholly new mind set approximately technological know-how, one who highlights its strengths and boundaries, its unrealized promise, and, especially, its unavoidable ambiguity. It additionally issues to a extra refined method of the main intractable difficulties of our time.

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Extra info for The Blind Spot: Science and the Crisis of Uncertainty

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40,41 The approach discussed in this letter relies on adding a gel structure to a preexisting membrane, rather than forming a membrane on a pre-cast gel. 42,43 Their technique, however, has not been shown to achieve sufficient membrane resistances for single-molecule measurements. Our approach maintains high membrane resistance by photopolymerizing the gel in situ around a high-quality membrane. Materials and methods Freestanding microchannel fabrication PDMS microchannels were fabricated by molding a liquid 10:1 PDMS base:crosslinker mixture (Dow Corning) around 200 µmdiameter silver wires and curing at 60 °C for 2 hours.

Y. "Synthesis studies of sputtering TiO2 films on poly(dimethylsiloxane) for surface modification" Colloid Surface A 272: 170-175 (2006). ; Roberts, R. ; Arnold, F. ; Quake, S. R. "Dynamic pattern formation in a vesicle-generating microfluidic device" Phys Rev Lett 86(18): 4163-4166 (2001). ; Roach, L. ; Ismagilov, R. F. "Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets" J Am Chem Soc 125(37): 11170-11171 (2003). ; Ismagilov, R. F. "Millisecond kinetics on a microfluidic chip using nanoliters of reagents" J Am Chem Soc 125(47): 14613-14619 (2003).

49 Combining these two techniques will allow for the facile, automated formation of very long-lived lipid bilayers: a capacity that will be valuable in both high-throughput screening and sensing applications. Conclusions There are many potential applications of membrane channel proteins in lipid bilayers; practical implementation of these applications, however, requires new methods for dealing with lipid bilayers, which are notoriously fragile and difficult to fabricate. We have developed two techniques which fill this demand.

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