By Karl Schügerl
Solvent Extraction in Biotechnology offers with the reco- very and purification of fundamental and secondary metabolites by means of solvent extraction. within the first half the response engineering ideas: definitions, thermodynamic basics, and approach types, the kinetics of mass move among levels with no and with chemical response in addition to extraction gear, that are very important for downstream processing in biotechnology, are thought of intimately. The particular a part of the ebook describes the restoration of low-molecular metabolites: alcohols, acids and antibiotics with natural solvents, carrier-modifier-solvent platforms, supercritical gases in addition to with liquid membrane strategies. a number of sensible examples are given for the restoration of other metabolites in addition to for the calculation of the extraction approaches worthy for apparatus layout. along with solvent extraction, novel separation thoughts with liquid membrane, microemulsion and reversed micelles also are provided. This booklet will introduce the biochemical engineer and procedure engineer to the restoration of goods from advanced cultivation broths through smooth concepts of solvent extraction and support them with procedure design.
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Extra info for Solvent Extraction in Biotechnology: Recovery of Primary and Secondary Metabolites
The equilibrium constant. In a similar case, A and ABC are insoluble in the aqueous phase, Band Care insoluble in the organic phase, but with slow rate determining reaction, an interfacial adsorption model can be used, which was developed by Volkel et al. . However, this model has only been used for copper extraction with a carrier in a liquid membrane and no application of this reactio_n type is known in biotechnology up to now; therefore, it is not under consideration here. 5 Symbols for Sect.
In others these units are combined. 1 Centrifugal Extraction Equipment 53 In centrifugal extractors (differential contact centrifugal extractors), no discrete stages can be recognized. , of several concentric perforated cylinders and work as "rotating perforated plate columns". This concept of using centrifugal force to achieve countercurrent mixing and separation was developed in the early 1930s. The principle of this design is to introduce the heavy phase close to the axis of a rotating container, while the light phase is introduced close to the periphery.
It is especially suitable for handling solvent and raffinate phases with small density differences. Two main types of extraction equipment can be distinguished: - centrifugal extractors and - centrifugal separators. Centrifugal separators are analogous to mixer-settlers, as in each of their stages a complete phase separation occurs. They are mixer-settlers, where in the settler the phase separation is accelerated with centrifugal force. Some of this equipment consists of separate mixer and settler units.