By Yi Yang
Side Reactions in Peptide Synthesis, based at the author’s educational and business event, and sponsored via an intensive assessment of the present literature, offers research of, and proposes recommendations to, the main often encountered facet reactions in the course of peptide and peptidomimetic synthesis.
This beneficial instruction manual is perfect for learn and technique chemists operating with peptide synthesis in diversified settings throughout educational, biotech, and pharmaceutical study and improvement.
While peptide chemistry is more and more popular, universal part reactions and their motives are frequently poorly understood or expected, inflicting pointless waste of fabrics and hold up.
Each bankruptcy discusses universal part reactions via certain chemical equations, proposed mechanisms (if any), theoretical historical past, and eventually, numerous attainable options to prevent or alleviate the desired facet response.
- Provides a scientific exam on the right way to troubleshoot and reduce the main common part reactions in peptide synthesis
- Gives chemists the history info and the sensible instruments they should effectively troubleshoot and enhance results
- Includes optimization-oriented research of aspect reactions in peptide synthesis for more suitable business approach improvement in peptidyl API (active pharmaceutical component) construction
- Answers the transforming into, international desire for superior, replicable techniques to prevent impurities and retain the integrity of the top product.
- Presents a radical dialogue of serious components in peptide synthesis that are usually overlooked or underestimated via chemists
- Covers reliable part and answer part methodologies, and gives plentiful references for additional exploration
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Extra resources for Side Reactions in Peptide Synthesis
Even though the liberated functional groups from the target peptide products are protected by the shielding effect of the added scavengers at the step of peptide cleavage and global deprotection, diverse side reactions could still unavoidably take place and corresponding impurities are generated. The core content of this chapter will be focused on the behavior, mechanism and potential solution for these side reactions invoked in the process of peptide cleavage and global deprotection. Side Reactions in Peptide Synthesis.
78. (a) Bodanszky M, Martinez J. Special Methods in Peptide Synthesis, Part B. New York: Academic; 1983:5; p. 112. (b) Barany G, Merrifield B. Methods of Peptide Synthesis, Part A. New York: Academic; 1980:2; p. 1. (c) Schröder E, Lübke K. Methods of Peptide Synthesis. New York: Academic; 1965:p. 1. 79. Nutt RF, Holly FW, Homnick C, Hirschmann R, Veber DF, Arison BH. J Med Chem. 1981;24:692–698. 80. Goodman M, Stueben K. J Am Chem Soc. 1962;84:1279–1283. 81. Grathwohl C, Wüthrich K. Biopolymers.
1988;31:960–966. 78. (a) Bodanszky M, Martinez J. Special Methods in Peptide Synthesis, Part B. New York: Academic; 1983:5; p. 112. (b) Barany G, Merrifield B. Methods of Peptide Synthesis, Part A. New York: Academic; 1980:2; p. 1. (c) Schröder E, Lübke K. Methods of Peptide Synthesis. New York: Academic; 1965:p. 1. 79. Nutt RF, Holly FW, Homnick C, Hirschmann R, Veber DF, Arison BH. J Med Chem. 1981;24:692–698. 80. Goodman M, Stueben K. J Am Chem Soc. 1962;84:1279–1283. 81. Grathwohl C, Wüthrich K.