By Ph. Fessas (auth.), Professor Dr. Constantin Papavasiliou, Assistant Professor Dr. Theophanis Cambouris, Professor Dr. Phaedon Fessas (eds.)
Estimates show that there are a few two hundred million heterozygous vendors of irregular hemoglobins genes around the globe, and tens of hundreds of thousands of seriously affected sufferers. powerful software of imaging concepts is key to strive against the ongoing improvement of the ailment and to make sure safe follow-up of the chronically ailing. this is often the 1st ebook to supply whole insurance of such radiologic purposes with either traditional and the main glossy imaging modalities. Interventional radiology, marrow transplantation, prenatal analysis by means of ultrasonography, and radiotherapy for bone marrow heterotopia also are featured.
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Note the lack of changes in the occipital squamosa, inferior to the internal occipital protuberance Fig. 6. Skull in thalassemia major. The diploic space is considerably widened in the frontal, parietal, and occipital bones. Hyperplastic marrow has perforated the outer table; the inner table remains intact All bones show a granular osteoporosis 25 26 Th. Cambouris Fig. 7. Skull in thalassemia major. The entire vault except for the squamous occiput is seriously affected by the disease. There are multiple radiating spicules perpendicular to the inner table of the skull caused by hyperplastic marrow, giving a hair-on-end appearance.
No horizontal striations were observed near the ends of the diaphyses of the elbow bones, and the cortex was not thinned. The contours of the elbow bones were normal. Conclusions As a result of our studies, we came to the conclusion that osseous X-ray changes do occur in thalassemia minor. The skull is the part of the skeleton most often affected: 38% of the carriers seem to have X -ray modifications in the skull. , in 23% and 18% of the carriers respectively. The ribs are unaffected. In other words, rarefying modifications of the humerus seem to be the most frequent abnormality next to those of the skull, while the lumbar spine presents bone rarefaction less frequently.
Cambouris 30 Fig. 11 b foramina are shown as round or ovallucencies in the center of the metacarpals or phalanges, usually nearer to the distal ends (Fig. 16 a, b). This finding is not pathognomonic of j3-thalassemia because it may also be encountered in patients with Gaucher's disease. Long Bones Transverse bands of increased density (growth lines) may be observed across the metaphyseal portions of the long bones in children with thalassemia major. They may persist in adult life, and they do not have any clinical significance (Fig.