Download New Avenues to Efficient Chemical Synthesis: Emerging by P.H. Seeberger, T. Blume PDF

By P.H. Seeberger, T. Blume

In smooth drug discovery and improvement, chemical synthesis is without doubt one of the key applied sciences. For the fast guidance of recent try compounds and drug improvement applicants, numerous cutting edge applied sciences with nice strength have emerged. This booklet bargains a compact assessment of the present prestige of those applied sciences and contains many real-life examples from and educational institutions.

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Extra resources for New Avenues to Efficient Chemical Synthesis: Emerging Technologies (Ernst Schering Foundation Symposium Proceedings)

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In this way, a flow channel length over 1 m length formatted as a serpentine within the area of the chip can be monitored. The system uses a patented focussing system (White 2003) to locate the channels and the focal depth, which obviates the need for an optical microscope or manual intervention. The optical head simultaneously interrogates a 30-fL sample with two colours of laser light and fluorescence intensity, fluorescence polarisation or fluorescent resonant energy transfer (FRET) is used to determine ligand binding.

54 . . . . 54 Abstract. In common with other producers of fine chemicals, the pharmaceutical industry can deploy flow microreactors to provide a more flexible production regime than is achievable with large-scale batch reactors. With monitoring of output flow, microreactors can be adjusted exquisitely to give enhanced and inherently safer protocols. Bulk production can be achieved through long run times or parallel reactors. However, microreactors can also be used advantageously in pharmaceutical R&D in other ways.

To maximise the conversion to products in this mixing mode, a series of many narrow slugs are therefore more effective than a single broad slug. It should be noted that, in contrast to diffusive mixing, mixing by differential electrophoretic mobilities does not result in dilution of the localised reagent concentra- 32 X. J. Haswell tions, enabling charged species to be concentrated in a specific region; as shown in Fig. 5b the product complex concentration is approximately six times the initial reactant concentration.

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