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By J. Thakore, B.E. Leonard

Significant melancholy and bipolar ailment are power enduring severe psychological health problems (SMI) with devastating results on psychosocial functioning and will culminate in suicide. over the last years, it has turn into obvious that topics with those stipulations may also advance the metabolic syndrome, that is a chain of obesity-related actual stipulations with an endocrine foundation. This ebook brings jointly experiences that support positioned into context precisely why matters with SMI strengthen weight problems, prediabetic prestige, overt variety 2 diabetes mellitus and similar cardiovascular occasions. the connection among prolactin and bone mineral density in topics lower than scientific remedy and the underlying dopaminergic mechanisms in addition to the immunological adjustments taking place as an essential component of SMI and their results on endocrine functionality are mentioned and reviewed. Psychiatrists, diabetologists, cardiologists, family members practitioners, public healthiness physicians in addition to simple technology researchers will locate worthwhile directions whilst screening for kind 2 diabetes mellitus and heart problems in SMI.

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79 Elmslie J, Mann J, Silverstone J: Determinants of overweight and obesity in patients with bipolar disorder. J Clin Psychiatry 2001;62:486–491. 80 Newcomer J: Second-generation (atypical) antipsychotics and metabolic effects. CNS Drugs 2005; 19(suppl 1):1–93. 81 Baptista T, De Mendoza S, Beaulieu S, Bermudez A, Martinez M: The metabolic syndrome during atypical antipsychotic drug treatment: mechanisms and management. Metab Syndr Relat Disord 2004;2:290– 307. 82 Newcomer J, Haupt D, Fucetola R, et al: Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia.

45 Carmina E, Bucchieri S, Esposito A, et al: Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance. J Clin Endocrinol Metab 2007;92:2500–2505. 46 Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143–3421. 22 47 Larsson B, Bengtsson C, Bjorntorp P, et al: Is abdominal body fat distribution a major explanation for the sex difference in the incidence of myocardial infarction?

69 Aronne L, Segal K: Weight gain in the treatment of mood disorders. J Clin Psychiatry 2003;64(suppl 8):22–30. 70 Baptista T, Teneud L, Contreras Q: Lithium and body weight gain. Pharmacopsychiatry 1995;28:35–44. 71 Levine S, Saltzman A: Lithium increases gastrointestinal tract weight of male or female rats but it increases body weight only in females. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:29– 33. 72 Vendsborg P, Rafaelson O: Lithium in man: effect on glucose intolerance and serum electrolytes.

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