By Thomas N. Sato (auth.), Cynthia A. Reinhart-King (eds.)
This quantity describes and discusses contemporary advances in angiogenesis learn. The chapters are equipped to handle all organic size scales of angiogenesis: molecular, mobile and tissue in either in vivo and in vitro settings. particular emphasis is given to novel methodologies and biomaterials which have been constructed and utilized to angiogenesis learn. Angiogenesis specialists from different fields together with engineering, phone and developmental biology, chemistry and physics could be invited to give a contribution chapters which specialise in the mechanical and chemical indications which impact and advertise angiogenesis.
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Am. J. Physiol. 267(3 Pt 1), C679–C687 (1994) 31. : ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. Gastroenterology 124(3), 692–700 (2003) 32. : Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. modulation by potassium channel blockade. J. Clin. Invest. 95(3), 1363–1369 (1995) 33. : Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene.
6 a Kinetics of liver SEC expansion and b hepatocyte mitosis during liver regeneration (n = 4). c Proposed schema describing the roles of SECs in liver regeneration. Upon partial hepatectomy (day 0), LSECs initiate the proliferation of proximal hepatocytes by exerting ‘‘inductive signals’’, possibly by releasing angiocrine factors. Day 4 post-PH, there is a significant liver SEC expansion (proliferative angiogenesis) to sustain hepatic reconstitution. Scale bars, 50 lm. Error bars, SEM Fig. 7 Partial hepatectomy induced VEGFR2-Id1 activation in LSECs mediates liver regeneration.
Substrate independence also allows for three-dimensional (3D) culture under controlled gradients, which is important because native vasculature is inherently 3D. , days or weeks, necessary to quantify the role of soluble gradients in collective behaviors such as path-finding , inosculation , and maturation  of nascent sprouts are only possible under stable concentration profiles. With microfluidic devices that apply specified, substrate-independent, stable gradients, we can quantitatively and multifactorially analyze how soluble gradients and other inputs contribute to angiogenesis.