By Gordon M. Barrow
Advent to Molecular Spectroscopy
Gordon M. Barrow
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Harpagoside has been shown to suppress LPS induced inducible NOS and COX-2 expression through inhibition of NF-κβ activation. This Devil’s claw extract is currently undergoing Phase 2 clinical trial for the treatment of hip and knee osteoarthritis. l Flavocoxid—It is a blend of natural flavonoids from Scutellaria baicalensis and Acacia catechu. It is generally used as medicinal food for the management of osteoarthritis. It works by inhibiting COX-1 and COX-2 and lipooxygenase enzyme system. It is currently undergoing Phase 1 clinical trial for the treatment of knee osteoarthritis.
Plants shall continue to be used worldwide for the treatment of disease and as a source of novel drug entities through research at both the academic and industrial levels. Despite the massive arsenal of clinical candidates developed by the pharmaceutical industries, an aversion has been seen by many members of the modern society and thus making herbal remedies a popular alternative for the treatments and eradication of diseases worldwide. FURTHER READING Anonymous, 1948–1976. Wealth of India, vol.
In such programs the incompatibility of crude extracts with high throughput assays can be addressed by some degree of prefractionation of extracts. A modified betulinic acid derivative having HIV maturation inhibitor action has been discovered by this approach and the compound is currently in Phase 2 clinical trials. 1 Whole Cell-Based Assay Method It helps in the assessment of specific molecular interactions between plant extract components and living cellular system. Moreover, information about drug penetration and binding with receptors are obtained at a very early stage from such studies.