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By C. R. Sirtori, A. V. Nichols, G. Franceschini

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14. H. Alexander, D. A. Johnson, J. Rosen, L. Jeraliek, N. Green, I. L. Weissman, and R. A. Lerner, Mimicking the alloantigenicity of proteins with chemically synthesized peptides differing in single amino acids, Nature 306 :697 (1983) • 15. D. J. Volkman, A. Ahmad, A. S. Fauci, and D. M. Neville, Selective abrogation of antigen-specific human B cell responses by antigen-ricin conjugates, ~ Exp. Med. 156:634 (1982). 16. E. S. Vitetta, K. A. Krolick, M. Miyama-Inala, W. Cushley, and J. W. Uhr, Immunotoxins: a new approach to cancer therapy, Science 219: 644 (19831.

Natl. Acad. Sci. USA, 79: 6861. , 1971, Genetic control of plasma cholesterol. Studies on squirrel monkeys. Arch. , 92: 37. M. , 1984, Polymorphism at the apoprotein-E locus in relation to risk of coronary disease. Clin. , 25: 310. , 1985, A partial cDNA clone for apolipoprotein B. Proc. Natl. Acad. Sci. USA, 82: 4983. , 1967, Fat transport in lipoproteins. New Eng!. , 276: 32. , 1982, Familial aggregation of total cholesterol, triglyceride and high-density lipoprotein-cholesterol in an Israeli population sample.

A further approach could be the production of human hybridomas. As described above, most human genetic polymorphisms which are defined immunologically rely on human isoantibodies. Thus, human monoclonal antibodies may prove to be better than 27 murine MABS for identifying apolipoprotein polymorphisms. The three major prerequisites for the production of human hybridomas are the availability of an immortal human cell partner, of immune human lymphocytes and of an efficient fusion system. There are now numerous appropriate human lymphoblastoid and myeloma cell lines which can serve as the immortal cell partner and a number of successful fusion protocols have been described and recently reviewed (17).

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