By Jacques Mortier
Equipped to permit scholars and artificial chemists to appreciate and extend on fragrant reactions coated in beginning classes, the e-book bargains an intensive and obtainable mechanistic rationalization of fragrant reactions regarding arene compounds.
• Surveys equipment used for getting ready arene compounds and their transformations
• Connects reactivity and technique with mechanism
• Helps readers observe fragrant reactions in a pragmatic context through designing syntheses
• Provides crucial information regarding suggestions used to figure out response mechanisms
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Extra info for Arene chemistry : reaction mechanisms and methods for aromatic compounds
By analyzing pseudo‐first‐order rate constants from reactions with various types of nucleophiles, the electrophilicities of numerous cationic species have been established. 8). 8 Electrophilicity parameters, E, for electrophiles 26–29. 20). Recently, this approach was used to predict the rate constant for the SEAr reactions involving iminium ion salts and pyrroles (for the rate‐determining C─C bond‐forming step) . Among the most reactive electrophiles, an informal benchmark of reactivity has been often cited— the SEAr reaction with nitrobenzene.
Since the C─H bond is not being broken in a rate‐determining step, there is usually little or no detectable kinetic isotope effect (KIE) for SEAr reactions . Thus, studies of KIEs are also consistent with the involvement of the σ‐complex. Larger KIEs have been observed in conversions involving weak electrophiles, such as nitrosations and diazonium coupling reactions [61c]. Several examples have been reported of SEAr reactions providing different products under thermodynamic and kinetic control.
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