Download Alkaline Phosphatase by Robert B. McComb PDF

By Robert B. McComb

There should be doubtless that alkaline phosphatase is among the so much broadly in­ vestigated of all enzymes. This has resulted from the ubiquity of its distribution, and from the benefit and sensitivity with which its job might be measured. regrettably, those wide-ranging yet usually superficial experimental reviews were up by means of in depth and systematic investigations in just a number of constrained components of the biochemistry and chemical pathology of alkaline phosphatase. the end result has been the buildup of a systematic literature of intimidating proportions, and the inevitable rediscovery of already­ identified evidence concerning the enzyme. Scientists are taught early of their careers that, within the phrases of Sir John Herschel, "Hasty generalization is the bane of technology. " however, moments arrive in all spheres of clinical task while generalization turns into crucial, to codify and to choose from the mass of information already collected, and to supply beginning issues for brand spanking new advancements and new traces of research. this can be very true in a box akin to alkaline phosphatase examine, within which very actual hazards exist that the seeds of primary figuring out can be misplaced amidst an unexamined harvest of empirical observations. The heritage of the research of alkaline phosphatase presents numerous cases while useful generalizations have emerged. sometimes, the conclusions drawn at the foundation of accessible facts have been incorrect; extra often, they've got stood the attempt of additional experimentation, and continuously, they've got supplied new insights into the character and correct­ ties of this enzyme.

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Extra info for Alkaline Phosphatase

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Isolation of 32P-labeled phosphorylserine from a purified preparation of alkaline bone phosphatase incubated with radioactive inorganic phosphate,Acta. OIem. , 13,1047,1959. 22 CHAPTER 2 149. Schwartz, J. , The phosphorylation of alkaline phosphatase, Proc. Natl. Acad. Sci. , 49, 871,1963. 150. , and Wilson, I. , Evidence for a phosphoryl-enzyme intermediate in alkaline phosphatase catalyzed reactions, Biochemistry, 8, 1042, 1969. 151. Aldridge, W. , Barman, T. , The rate of formation and decomposition of phosphorylphosphatase (Escherichia coli), Biochem.

The phosphotransferase activity of phosphatase. II. Studies with purified alkaline phosphomonoesterases and some substrate specific phosphatases, Biochem. , 70, 139, 1958. 78. Bailie, M. , and Morton, R. , Comparative properties of microsomes from cow's milk and from mammary gland. I. Enzymic activities, Biochem. ,69,35,1958. 79. Malamy, M. , and Horecker, B. , Purification and crystallization of the alkaline phosphatase of Escherichia coli, Biochemistry, 3,1893,1964. 80. Kay, H. , and Graham, W.

Robinson, J. , and Pierce, J. , Differential action of neuramidase on human serum alkaline phosphatase, Nature (London), 204,472, 1964. 226. , Production of antibodies against dog intestinal phosphatase, J. Bioi. , 206, 361, 1954. 227. , Specificity of dog intestinal phosphatase antiserum, J. Bioi. ,206, 369, 1954. 228. Lehmann, F. , Immunological relationship between human placental and intestinal alkaline phosphatase, Qin. Chim. Acta, 65, 257,1975. 229. , Alkaline phosphatase, Ann. Intern. , 67, 183, 1967.

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